Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth

Specific stem cell populations within dental mesenchymal tissues guarantee tooth homeostasis and regeneration throughout life. The decision between renewal differentiation of cells is greatly influenced by interactions with stromal extracellular matrix molecules that form the tissue specific niches. Cxcl12 chemokine a general marker plays fundamental roles in maintenance, mobilization migration cells. aim this study was to exploit Cxcl12-GFP transgenic mice expression patterns putative niches intact injured teeth. We showed endothelial expressed pulp both molars incisors. Isolated non-endothelial Cxcl12+ cultured different conditions vitro exhibited adipogenic osteogenic markers, thus suggesting these possess multipotent fates. Taken together, our results show widely teeth highlight its importance as key component various